Thermally unstable gating of the most common cystic fibrosis mutant channel (&#916;F508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.

Wang, Wei; Okeyo, George O; Tao, Binli; Hong, Jeong S; Kirk, Kevin L

Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.

Wang, Wei; Okeyo, George O; Tao, Binli; Hong, Jeong S; Kirk, Kevin L.

Afiliação

Wang W; Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294. Electronic address: weiwang@uab.edu.
Okeyo GO; Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Tao B; Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Hong JS; Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Kirk KL; Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294.

J Biol Chem ; 286(49): 41937-41948, 2011 Dec 09.

Article em En | MEDLINE | ID: mdl-21965669

Assuntos

Regulador de Condutância Transmembrana em Fibrose Cística/genética; Citosol/química; Mutação; Trifosfato de Adenosina/química; Transporte Biológico; Linhagem Celular; Citosol/metabolismo; Temperatura Alta; Humanos; Modelos Genéticos; Nucleotídeos/genética; Técnicas de Patch-Clamp; Ligação Proteica; Desnaturação Proteica; Dobramento de Proteína; Estrutura Terciária de Proteína; Temperatura

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Regulador de Condutância Transmembrana em Fibrose Cística / Citosol / Mutação Tipo de estudo: Guideline / Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2011 Tipo de documento: Article

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