Inhibition of nonmammalian glycosidases by azetidine iminosugars derived from stable 3,5-di-O-triflates of pentoses.
Org Lett
; 13(21): 5834-7, 2011 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-21985023
ABSTRACT
Efficient ring closure of stable crystalline 3,5-di-O-triflates of pentofuranosides with amines to form azetidines allowed preliminary evaluation of four-ring iminosugars as glycosidase inhibitors; significant and specific inhibition of nonmammalian α-glucosidases is shown by L-xylo- and L-arabino-iminosugar azetidines.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Azetidinas
/
Inibidores Enzimáticos
/
Imino Açúcares
/
Glicosídeo Hidrolases
Limite:
Animals
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido