p53 Family: Role of Protein Isoforms in Human Cancer.
J Nucleic Acids
; 2012: 687359, 2012.
Article
em En
| MEDLINE
| ID: mdl-22007292
ABSTRACT
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
J Nucleic Acids
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos