Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes.
Nucleic Acids Res
; 40(Database issue): D978-83, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22080562
ABSTRACT
The identification of a constantly increasing number of genes whose mutations are causally implicated in tumor initiation and progression (cancer genes) requires the development of tools to store and analyze them. The Network of Cancer Genes (NCG 3.0) collects information on 1494 cancer genes that have been found mutated in 16 different cancer types. These genes were collected from the Cancer Gene Census as well as from 18 whole exome and 11 whole-genome screenings of cancer samples. For each cancer gene, NCG 3.0 provides a summary of the gene features and the cross-reference to other databases. In addition, it describes duplicability, evolutionary origin, orthology, network properties, interaction partners, microRNA regulation and functional roles of cancer genes and of all genes that are related to them. This integrated network of information can be used to better characterize cancer genes in the context of the system in which they act. The data can also be used to identify novel candidates that share the same properties of known cancer genes and may therefore play a similar role in cancer. NCG 3.0 is freely available at http//bio.ifom-ieo-campus.it/ncg.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bases de Dados Genéticas
/
Genes Neoplásicos
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Redes Reguladoras de Genes
Limite:
Humans
Idioma:
En
Revista:
Nucleic Acids Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália