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Acute and 28-day repeated dose toxicology studies in mice with aryloxyalkanoate dioxygenase (AAD-1) protein expressed in 2,4-D tolerant DAS-40278-9 maize.
Stagg, Nicola J; Thomas, Johnson; Herman, Rod A; Juberg, Daland R.
Afiliação
  • Stagg NJ; Dow AgroSciences, LLC, Indianapolis, IN 46268, USA. njstagg@dow.com
Regul Toxicol Pharmacol ; 62(2): 363-70, 2012 Mar.
Article em En | MEDLINE | ID: mdl-22100718
DAS-40278-9 maize (corn) plants have been genetically modified by the insertion of the aad-1 gene (aryloxyalkanoate dioxygenase), which confers tolerance to 2,4-dichlorophenoxyacetic acid (2,4-D) and aryloxyphenoxypropionate (AOPP) acetyl coenzyme A carboxylase (ACCase) inhibitors ("fop" herbicides) to enable the effective use of these herbicides on maize. The aad-1 gene, derived from Sphingobium herbicidovorans, encodes the aryloxyalkanoate dioxygenase (AAD-1) enzyme. As part of the safety assessment of the AAD-1 protein expressed in maize, acute and repeated dose mammalian toxicology studies were conducted. AAD-1 protein (heterologously produced) was orally administered to mice at a dose of 2000mg/kg, and no acute lethality or adverse effects were observed. Similarly, no adverse effects were observed in mice in a 28-day repeated-dose dietary toxicity study that incorporated the AAD-1 protein into diets at concentrations up to 1000-fold greater than the highest estimate of human exposure to maize. These results support the conclusion that the AAD-1 protein, as expressed in biotechnology derived DAS-40278-9 maize, represents a negligible risk to human health.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Plantas Geneticamente Modificadas / Zea mays / Testes de Toxicidade Aguda / Dioxigenases / Ácido 2,4-Diclorofenoxiacético / Herbicidas Limite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Plantas Geneticamente Modificadas / Zea mays / Testes de Toxicidade Aguda / Dioxigenases / Ácido 2,4-Diclorofenoxiacético / Herbicidas Limite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Estados Unidos