Prognostic factors for idiopathic pulmonary fibrosis: clinical, physiologic, pathologic, and molecular aspects.
Sarcoidosis Vasc Diffuse Lung Dis
; 28(2): 102-12, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-22117501
ABSTRACT
BACKGROUND:
Previous studies identified clinical and physiologic factors of idiopathic pulmonary fibrosis (IPF) that are related to an increased risk of mortality. But there are few studies about histologic and molecular approach.OBJECTIVE:
We investigated whether the C-reactive protein (CRP), fibroblastic foci, phosphorylated Smad2/3 (p-Smad2/3), tumor growth factor-beta (TGF-beta), TGF-beta receptor II (TbetaRII), and the polymorphism of the TGF-beta1 codon 10 are associated with the progression of IPF patients.DESIGN:
Eighty-six IPF patients who underwent surgical lung biopsies were examined. For each patient, clinical and physiologic parameters were investigated, and we performed immunohistochemical staining for p-Smad2/3 and TbetaRII, and genotyping of the TGF-beta1 codon 10 polymorphism.RESULTS:
Age at diagnosis, gender, symptom duration, and smoking status did not show a significant association. However, the amount of smoking (p = 0.002), severe reduction in the percentages of predicted forced vital capacity (p = 0.013) and diffusion lung capacity of carbon monoxide (p = 0.023), CRP (p = 0.009) at diagnosis, and fibroblastic foci (p = 0.026) were associated with a poor prognosis. Cellularity, fibrosis, expression level of p-Smad2/3 and TbetaRII, and genotype of the TGF-beta1 codon 10 polymorphism did not have a statistically significant association with the prognosis.CONCLUSION:
This study confirmed the amount of smoking, abrupt decrease in follow-up pulmonary function parameters, fibroblastic foci, and increased levels of CRP concentration at diagnosis were significantly associated with poor survival. Larger studies are required to confirm all prognostic factors including CRP.
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Bases de dados:
MEDLINE
Assunto principal:
Fibrose Pulmonar Idiopática
/
Pulmão
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Sarcoidosis Vasc Diffuse Lung Dis
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
ANGIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article