Ameliorative effect of methanol extract of Rubia cordifolia in N-nitrosodiethylamine-induced hepatocellular carcinoma.
Pharm Biol
; 50(3): 376-83, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22133091
ABSTRACT
CONTEXT Rubia cordifolia Linn. (Rubiaceae) is a medicinal plant used in the ayurvedic system of medicine. It is also known as Indian Madder or Manjistha and is traditionally used as an antiinflammatory, antiseptic, and galactopurifier, but its anticancer propertis are yet not known. OBJECTIVE:
The ameliorative effect of the Rubia cordifolia methanol extract on N-nitrosodiethylamine-induced experimental hepatocellular carcinogenesis in rats. MATERIALS ANDMETHODS:
Changes in liver weight, serum markers of liver damage, hydroxyl radicals, lipid peroxidation, levels of enzymic and nonenzymic antioxidants; mitochondrial and respiratory chain enzymes were also investigated using various biochemical parameters and histopathological studies. Male albino rats of Wistar strain were divided into four groups for a study period of 3 months. Animals of group I and group IV served as control and drug control, respectively. Hepatocellular carcinoma was induced in animals of groups II and III with 0.02% N-nitrosodiethylamine.RESULTS:
Upon Rubia cordifolia methanol extract co-treatment (250, 500, and 750 mg/kg bodyweight) in group III alone levels of serum marker enzymes and antioxidants increased significantly in a dose-dependent manner. The levels of hydroxyl radicals and lipid peroxidation decreased. Mitochondrial enzymes and respiratory chain enzymes, which were decreased in N-nitrosodiethylamine-induced rats, increased significantly in RC treated rats. Further histological analysis of liver confirmed the prevention of pathological changes caused by N-nitrosodiethylamine on Rubia cordifolia supplementation. DISCUSSION ANDCONCLUSION:
These findings demonstrate that Rubia cordifolia can be a source of potent antioxidants for treatment of diseases such as cancer.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Carcinoma Hepatocelular
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Rubia
/
Neoplasias Hepáticas Experimentais
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Pharm Biol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Índia