The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.
Proc Natl Acad Sci U S A
; 108(51): E1399-407, 2011 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-22135456
ABSTRACT
Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18. This cytokine is produced at high levels in inflammatory diseases, including allergy and autoimmunity, and is known to induce IgE production in mice. Here we provide evidence that IL-18 is directly coupled to induction of self-reactive IgM and IgG antibody responses and recruitment of innate B2 B cells residing in the marginal zone of the spleen. Moreover, the data suggest that the B-cell activation occurs predominantly in splenic extrafollicular plasma cell foci and is regulated by natural killer T (NKT) cells that prevent formation of mature germinal centers. We also find evidence that NKT cells control this type of B-cell activation via cytotoxicity mediated by both the perforin and CD95/CD178 pathways. Thus, NKT cells regulate innate antibody responses initiated by an inflammatory stimulus, suggesting a general mechanism that regulates B-cell behavior in inflammation and autoreactivity.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
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Linfócitos T
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Interleucina-18
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Suécia