Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens.
Vaccine
; 30(13): 2256-72, 2012 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-22306376
ABSTRACT
Liposomes (phospholipid bilayer vesicles) are versatile and robust delivery systems for induction of antibody and T lymphocyte responses to associated subunit antigens. In the last 15 years, liposome vaccine technology has matured and now several vaccines containing liposome-based adjuvants have been approved for human use or have reached late stages of clinical evaluation. Given the intensifying interest in liposome-based vaccines, it is important to understand precisely how liposomes interact with the immune system and stimulate immunity. It has become clear that the physicochemical properties of liposomal vaccines - method of antigen attachment, lipid composition, bilayer fluidity, particle charge, and other properties - exert dramatic effects on the resulting immune response. Here, we present a comprehensive review of the physicochemical properties of liposomal vaccines and how they influence immune responses. A discussion of novel and emerging immunomodulators that are suitable for inclusion in liposomal vaccines is also presented. Through a comprehensive analysis of the body of liposomal vaccine literature, we enumerate a series of principles that can guide the rational design of liposomal vaccines to elicit immune responses of a desired magnitude and quality. We also identify major unanswered questions in the field, pointing the direction for future study.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Vacinas
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Desenho de Fármacos
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Lipossomos
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Antígenos
Tipo de estudo:
Qualitative_research
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Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2012
Tipo de documento:
Article