[Assessing the contribution of a standardized method in defining the tumor bed using surgical clips in breast cancer]. / Évaluation de l'apport d'une méthode standardisée dans la définition du lit tumoral à l'aide de clips chirurgicaux dans le cancer du sein.
Cancer Radiother
; 16(2): 100-6, 2012 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-22310324
ABSTRACT
PURPOSE OF THE STUDY The objective of this study was to compare prospectively the delineations of tumour bed after breast conserving surgery from two techniques for defining the target volume. PATIENTS AND METHODS:
Sixteen patients treated by lumpectomy with development of surgical clips were included. For each patient, four radiation oncologists delineated the clinical target volume (CTV boost) following its own method (technique 1) or using a predefined methodology (technique 2), the diameter to be applied around each clip relative to the risk of local recurrence. Factors taken into account to adjust the volume were tumour size, age, surgical margins and the presence of extensive ductal carcinoma. We then analyzed the factors varying the volume and variation of delineation for each method by calculating the concordance index Kappa index and overlap.RESULTS:
For all 16 patients, the volume delineated was nearly identical 29.65 cm(3) with technique 1 and 33.54 cm(3) with technique 2 (P=0.6). The correlation was higher with technique 2 over technique 1, with KI from 0.146 to 0.285 (P=0.0001) and an OV of 0.302 to 0.458 (P=0.0002).CONCLUSION:
Our study shows that within the same institute, there is a great variability in CTV delineation boost, even in the presence of surgical clips. A standardized approach to adjusting the volume of relapse risk factors has improved the consistency.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
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Humans
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Middle aged
Idioma:
Fr
Revista:
Cancer Radiother
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França