Factors associated to duration of hepatitis a outbreaks: implications for control.
PLoS One
; 7(2): e31339, 2012.
Article
em En
| MEDLINE
| ID: mdl-22355358
ABSTRACT
Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 10(5) persons-year) were reported. Factors associated with shorter duration were time to intervention (ORâ=â0.96; 95% CI 0.94-0.98) and school setting (ORâ=â0.39; 95% CI 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (ORâ=â0.96; 95% CI 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Controle de Doenças Transmissíveis
/
Surtos de Doenças
/
Vírus da Hepatite A
/
Hepatite A
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Espanha