9α-Hy-droxy-12-{[4-(4-meth-oxy-phen-yl)piperazin-1-yl]meth-yl}-4,8-dimethyl-3,14-dioxatricyclo-[9.3.0.0]tetra-dec-7-en-13-one.
Acta Crystallogr Sect E Struct Rep Online
; 68(Pt 3): o589-90, 2012 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-22412505
ABSTRACT
The title compound, C(26)H(36)N(2)O(5), was synthesized from 9α-hy-droxy-parthenolide (9α-hy-droxy-4,8-dimethyl-12-methyl-ene-3,14-dioxatricyclo-[9.3.0.0(2,4)]tetra-dec-7-en-13-one), wich was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The mol-ecule is built up from fused five- and ten-membered rings with the meth-oxy-phenyl-piperazine group as a substituent. The ten-membered ring adopts an approximate chair-chair conformation, while the piperazine ring displays a chair conformation and the five-membered ring a flattened envelope conformation; the C(H)-C-C(H) atoms representing the flap lie out of the mean plane through the remaining four atoms by 0.343â
(3)â
Å. The dihedral angle between the mean planes of the ten-membered ring and the lactone ring is 18.12â
(14)°. An intra-molecular O-Hâ¯N hydrogen bond occurs. The crystal structure features weak C-Hâ¯O inter-actions.
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MEDLINE
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En
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Acta Crystallogr Sect E Struct Rep Online
Ano de publicação:
2012
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Article