Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity.
Hum Brain Mapp
; 34(9): 2025-31, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-22505278
ABSTRACT
The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Encéfalo
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Fatores de Transcrição Hélice-Alça-Hélice Básicos
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Fibras Nervosas Mielinizadas
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Proteínas do Tecido Nervoso
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Hum Brain Mapp
Assunto da revista:
CEREBRO
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido