Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting.
Bioorg Med Chem Lett
; 22(10): 3418-24, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22521645
ABSTRACT
Three chemical modification methods of carboxymethylation, quaternization and hydroxypropylation were used to synthesize water-soluble chitosan derivatives. In order to study the feasibility of these chitosan derivatives as backbones of nuclear imaging agents, folic acid (FA) and Technetium-99m were introduced onto the water-soluble chitosan chains. The bifunctional chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to the folate grafted chitosan derivatives for chelating with radionuclides such as (64)Cu and (68)Ga. The structures of these new ligands were characterized with multiple methods. The solubility and stability of the (99m)Tc-complexes were both favorable. Further study of their radiochemical and biological properties will be performed to evaluate the usefulness of these water-soluble chitosan derivatives for nuclear imaging agent design.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Receptores de Superfície Celular
/
Quitosana
/
Ácido Fólico
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China