Heterogeneous drying stresses in stratum corneum.
Biophys J
; 102(11): 2424-32, 2012 Jun 06.
Article
em En
| MEDLINE
| ID: mdl-22713557
ABSTRACT
We study the drying of stratum corneum, the skin's outermost layer and an essential barrier to mechanical and chemical stresses from the environment. Even though stratum corneum exhibits structural features across multiple length-scales, contemporary understanding of the mechanical properties of stratum corneum is based on the assumption that its thickness and composition are homogeneous. We quantify spatially resolved in-plane traction stress and deformation at the interface between a macroscopic sample of porcine stratum corneum and an adherent deformable elastomer substrate. At length-scales greater than a millimeter, the skin behaves as a homogeneous elastic material. At this scale, a linear elastic model captures the spatial distribution of traction stresses and the dependence of drying behavior on the elastic modulus of the substrate. At smaller scales, the traction stresses are strikingly heterogeneous and dominated by the heterogeneous structure of the stratum corneum.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fenômenos Fisiológicos da Pele
/
Estresse Fisiológico
/
Dessecação
Limite:
Animals
Idioma:
En
Revista:
Biophys J
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos