Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory.
Cereb Cortex
; 23(8): 2007-14, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-22767632
ABSTRACT
Prolyl endopeptidase (PREP) is a phylogenetically conserved serine protease and, in humans and rodents, is highly expressed in the brain. Several neuropeptides associated with learning and memory and neurodegenerative disorders have been proposed to be the substrates for PREP, suggesting a possible role for PREP in these processes. However, its physiological function remains elusive. Combining genetic, anatomical, electrophysiological, and behavioral approaches, we show that PREP genetrap mice have decreased synaptic spine density in the CA1 region of the hippocampus, reduced hippocampal long-term potentiation, impaired hippocampal-mediated learning and memory, and reduced growth-associated protein-43 levels when compared with wild-type controls. These observations reveal a role for PREP in mediating hippocampal plasticity and spatial memory formation, with implications for its pharmacological manipulation in diseases related to cognitive impairment.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sinapses
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Serina Endopeptidases
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Potenciação de Longa Duração
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Aprendizagem em Labirinto
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Espinhas Dendríticas
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Região CA1 Hipocampal
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Memória
Limite:
Animals
Idioma:
En
Revista:
Cereb Cortex
Assunto da revista:
CEREBRO
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos