Mechanisms of Drosophila Dscam mutually exclusive splicing regulation.
Biochem Soc Trans
; 40(4): 804-9, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22817738
ABSTRACT
Alternative splicing of pre-mRNA is a major mechanism to increase protein diversity in higher eukaryotes. Dscam, the Drosophila homologue of human DSCAM (Down's syndrome cell adhesion molecule), generates up to 38016 isoforms through mutually exclusive splicing in four variable exon clusters. This enormous molecular diversity is functionally important for wiring of the nervous system and phagocytosis of invading pathogens. Current models explaining this complex splicing regulation include a default repressed state of the variable exon clusters to prevent the splicing together of adjacent exons, the presence of RNA secondary structures important for the release of one specific variable exon from the repressed state and combinatorial interaction of RNA-binding proteins for choosing a specific exon.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
/
Proteínas de Ligação a RNA
/
Proteínas de Drosophila
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido