Xanthine oxidase inhibitors from Vietnamese Blumea balsamifera L.
Phytother Res
; 26(8): 1178-81, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22821854
ABSTRACT
From the MeOH extract of the aerial part of Blumea balsamifera L., a new dihydroflavonol, (2R,3S)-(-)-4'-O-methyldihydroquercetin (1), together with seven known compounds has been isolated. Their structures were elucidated on the basis of spectroscopic data. Compounds 1-4 and 6-8 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compounds 1, 6 and 8 showed more potent inhibitory activity, with IC50 values ranging from 0.23 to 1.91 µM, than that of a positive control allopurinol (IC50 2.50 µM).
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Quercetina
/
Xantina Oxidase
/
Asteraceae
/
Inibidores Enzimáticos
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Vietnã