Daily schedule for high-dose-rate brachytherapy in postoperative treatment of endometrial carcinoma.
Clin Transl Oncol
; 15(2): 111-6, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-22855177
ABSTRACT
PURPOSE:
To analyze the results of daily high-dose-rate brachytherapy (HDRBT) on local control and toxicity in the postoperative treatment of endometrial carcinoma (EC). MATERIALS ANDMETHODS:
From January 2007 to September 2010, 112 patients were treated with HDRBT after surgery for EC. FIGO staging 24-IA, 48-IB, 14-II, 12-IIIA, 2-IIIB, 8-IIIC1 and 4-IIIC2. Pathology 99/112 endometrioid and 23/112 other types. Radiotherapy patients were divided into two groups-Group 1 (70/112) consists of external beam irradiation (EBI) plus HDRBT (2 fractions of 5-6 Gy) and Group 2 (42/112) consists of HDRBT alone (4 fractions of 5-6 Gy). Toxicity evaluation RTOG scores for bladder and rectum, and the objective criteria of LENT-SOMA for vagina. Statistics bivariate analysis of Chi-square and Fisher exact tests.RESULTS:
With a mean follow-up of 29.52 months (range 9.60-53.57) no patient developed vaginal-cuff relapse. In Group 1 early toxicity appeared in 9 % in rectum, 8.5 % in bladder (G1-G2) and 1.4 % in vagina (G1); late toxicity was present in 8.5 % in rectum (all G1-G2 but 1 G3) and in 25 % in vagina (all G1-G2 but one G4). In Group 2, 9.4 % developed G1-G2 bladder and 6.9 % acute vagina (G1-G2) toxicity. Only 2.3 % had a G1 rectal score and 6.9 % had G1-G2 as vaginal scores for late problems.CONCLUSIONS:
(1) Daily HDRBT using two fractions of 5-6 Gy after EBI and four fractions of 5-6 Gy as exclusive treatment was a safe regime. (2) Group 1 showed a higher incidence of late vaginal toxicity.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Braquiterapia
/
Neoplasias do Endométrio
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Espanha