Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP.
Cancer Invest
; 30(8): 583-92, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22909050
ABSTRACT
Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion were analyzed using trypsin-2 over-expressing human tongue squamous cell carcinoma cells (Try2-HSC-3) in vitro and in vivo. The invasion of Try2-HSC-3 cells was increased in mouse xenografts and human organotypic model. Trypsin-2 activated proMT1-MMP, as well as altered the expression of TJ protein claudin-7. In conclusion, trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms.
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Bases de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Tripsinogênio
/
Neoplasias da Língua
/
Carcinoma de Células Escamosas
/
Tripsina
/
Junções Íntimas
/
Metaloproteinase 14 da Matriz
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Finlândia