Nanoparticles and phage display selected peptides for imaging and therapy of cancer.
Recent Results Cancer Res
; 194: 133-47, 2013.
Article
em En
| MEDLINE
| ID: mdl-22918758
ABSTRACT
Molecular imaging probes are a special class of pharmaceuticals that target specific biochemical signatures associated with disease and allow for noninvasive imaging on the molecular level. Because changes in biochemistry occur before diseases reach an advanced stage, molecular imaging probes make it possible to locate and stage disease, track the effectiveness of drugs, treat disease, monitor response, and select patients to allow for more personalized diagnosis and treatment of disease. Targeting agents radiolabeled with positron emitters are of interest due to their ability to quantitatively measure biodistribution and receptor expression to allow for optimal dose determinations. (68)Ga is a positron emitter, which allows for quantitative imaging through positron emission chromatography (PET). The availability of (68)Ga from a generator and its ability to form stable complexes with a variety of chelates hold promise for expanding PET utilization to facilities unable to afford their own cyclotron. Nanoparticles conjugated with various proteins and peptides derived from phage display that can be selectively targeted are being developed and evaluated for guided imaging and therapy. Herein we highlight some initial efforts in combining the enhanced selectivity of nanoparticles and peptides with (68)Ga for use as molecular imaging probes.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biblioteca de Peptídeos
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Compostos Radiofarmacêuticos
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Nanopartículas Metálicas
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Radioisótopos de Gálio
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Recent Results Cancer Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos