Enantioseparation of α-hydroxy acids by chiral ligand exchange CE with a dual central metal ion system.
Electrophoresis
; 33(18): 2920-4, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22930546
ABSTRACT
Using two kinds of central metal ions in a background electrolyte, ligand exchange CE was investigated for the simultaneous enantioseparation of dl-malic, dl-tartaric, and dl-isocitric acids. Ligand exchange CE with 100 mM d-quinic acid as a chiral selector ligand and 10 mM Cu(II) ion as a central metal ion could enantioseparate dl-tartaric acid but not dl-malic acid or dl-isocitric acid. A dual central metal ion system containing 0.5 mM Al(III) ion in addition to 10 mM Cu(II) ion in the background electrolyte enabled the simultaneous enantioseparation of the three α-hydroxy acids. These results suggest that the use of a dual central metal ion system can be useful for enantioseparation by ligand exchange CE.
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Bases de dados:
MEDLINE
Assunto principal:
Eletroforese Capilar
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Metais Pesados
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Hidroxiácidos
Idioma:
En
Revista:
Electrophoresis
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Japão