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Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data.
Dasmeh, Pouria; Davis, Randall W; Kepp, Kasper P.
Afiliação
  • Dasmeh P; Technical University of Denmark, DTU Chemistry, DK 2800 Kongens Lyngby, Denmark.
Article em En | MEDLINE | ID: mdl-23085290
ABSTRACT
This paper presents an integrated model of convective O(2)-transport, aerobic dive limits (ADL), and thermochemical data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations in Mb on the dive limits of Weddell seals (Leptonychotes weddellii). We find that wild-type Mb traits are only superior under specific behavioral and physiological conditions that critically prolong the ADL, action radius, and fitness of the seals. As an extreme example, the mutations in the conserved His-64 reduce ADL up to 14±2min for routine aerobic dives, whereas many other mutations are nearly neutral in terms of ADL and the inferred fitness. We also find that the cardiac system, the muscle O(2)-store, animal behavior (i.e. pre-dive ventilation), and the oxygen binding affinity of Mb, K(O(2)), have co-evolved to optimize dive duration at routine aerobic diving conditions, suggesting that such conditions are mostly selected upon in seals. The model is capable of roughly quantifying the physiological impact of single-protein mutations and thus bridges an important gap between animal physiology and molecular (protein) evolution.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Focas Verdadeiras / Mergulho / Mioglobina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Comp Biochem Physiol A Mol Integr Physiol Assunto da revista: BIOLOGIA MOLECULAR / FISIOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Focas Verdadeiras / Mergulho / Mioglobina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Comp Biochem Physiol A Mol Integr Physiol Assunto da revista: BIOLOGIA MOLECULAR / FISIOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Dinamarca