[Study on relationship between expression of podoplanin and lymph node metastasis in oral squamous cell carcinoma].
Shanghai Kou Qiang Yi Xue
; 21(4): 437-41, 2012 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-23135121
ABSTRACT
PURPOSE:
In oral squamous cell carcinoma(OSCC) and normal oral tissues, podoplanin was used to mark lymphatic tract and recorded the lymphatic vessel density (LVD) by corresponding tissue. The aim of this study was to evaluate LVD in correlation with lymphnode metastases in patients with OSCC.METHODS:
The expressions of VEGF-C antibodies and anti-podoplanin were detected in 21 normal oral tissues and 88 paraffin sections of OSCC by immunohistochemistry(S-P); Determination of LVD (assessed by immunostaining for podoplanin) was performed as suggested by Weidner, the numerical value expressed by x±s Intratumoral lymphatic vessels (I-LVD) and peritumoral lymphatic vessels (P-LVD) were assessed, respectively. Data was analyzed with SPSS 13.0 software package and t test was used for comparative analysis of LVD between normal oral tissues and OSCC tissue and LVD (including P-LVD and ILVD) of the lymph node metastasis and without lymph node metastasis.RESULTS:
There was significant difference between LVD of normal control tissues, peritumoral and intratumoral tissues.The intratumoral lymphatic vessels (ILVD) were small and collapsed, while the peritumoral ones were large and dilated. The PLVD's density with lymph node metastasis(14.270±4.610) was significantly higher than that without lymph node metastasis (9.450±2.411, P<0.05).CONCLUSION:
The results indicated that peritumoral lymphangiogenesis may have an important impact on lymph node metastasis in OSCC.
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Bases de dados:
MEDLINE
Assunto principal:
Linfangiogênese
/
Metástase Linfática
Limite:
Humans
Idioma:
Zh
Revista:
Shanghai Kou Qiang Yi Xue
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
China