Daptomycin serum levels in critical patients undergoing continuous renal replacement.
J Chemother
; 24(5): 253-6, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-23182044
ABSTRACT
BACKGROUND:
Daptomycin pharmacokinetics has not been extensively studied in patients undergoing continuous renal replacement therapy (CRRT).METHODS:
The aim of the study was to collect pharmacokinetics and clinical data of patients undergoing CRRT and receiving daptomycin therapy. Daptomycin was measured using an isocratic high-performance liquid chromatography technique.RESULTS:
Three patients with bloodstream infection underwent CVVHD and three CVVHDF. CVVHDF patients had significantly lower mean AUC(0-24) and C(max) values. A significant decrease in plasma levels was observed in a CVVHDF patient using 'high cut-off' hemofilters.CONCLUSION:
Increasing doses of daptomycin should be considered in critical patients, especially those undergoing CVVHDF.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Diálise Renal
/
Daptomicina
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Chemother
Assunto da revista:
ANTINEOPLASICOS
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália