(89)Zr-labeled paramagnetic octreotide-liposomes for PET-MR imaging of cancer.
Pharm Res
; 30(3): 878-88, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-23224977
ABSTRACT
PURPOSE:
Dual-modality PET/MR platforms add a new dimension to patient diagnosis with high resolution, functional, and anatomical imaging. The full potential of this emerging hybrid modality could be realized by using a corresponding dual-modality probe. Here, we report pegylated liposome (LP) formulations, housing a MR T(1) contrast agent (Gd) and the positron-emitting (89)Zr (half-life 3.27 days), for simultaneous PET and MR tumor imaging capabilities.METHODS:
(89)Zr oxophilicity was unexpectedly found advantageous for direct radiolabeling of preformed paramagnetic LPs. LPs were conjugated with octreotide to selectively target neuroendocrine tumors via human somatostatin receptor subtype 2 (SSTr2). (89)Zr-Gd-LPs and octreotide-conjugated homolog were physically, chemically and biologically characterized.RESULTS:
(89)Zr-LPs showed reasonable stability over serum proteins and chelator challenges for proof-of-concept in vitro and in vivo investigations. Nuclear and paramagnetic tracking quantified superior SSTr2-recognition of octreotide-LP compared to controls.CONCLUSIONS:
This study demonstrated SSTr2-targeting specificity along with direct chelator-free (89)Zr-labeling of LPs and dual PET/MR imaging properties.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Zircônio
/
Octreotida
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Tumores Neuroendócrinos
/
Meios de Contraste
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Gadolínio
/
Lipossomos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharm Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos