The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.
Genes Dev
; 26(24): 2684-9, 2012 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-23249732
ABSTRACT
Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centriole duplication occurs once per cell cycle and is controlled by Polo-like kinase 4 (Plk4). We showed previously that Plk4 phosphorylates itself to promote its degradation by the proteasome. Here we demonstrate that this autoregulated instability controls the abundance of endogenous Plk4. Preventing Plk4 autoregulation causes centrosome amplification, stabilization of p53, and loss of cell proliferation; moreover, suppression of p53 allows growth of cells carrying amplified centrosomes. Plk4 autoregulation thus guards against genome instability by limiting centrosome duplication to once per cell cycle.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Proteínas Serina-Treonina Quinases
/
Centrossomo
Limite:
Humans
Idioma:
En
Revista:
Genes Dev
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos