6-Oxo and 6-thio purine analogs as antimycobacterial agents.
Bioorg Med Chem
; 21(7): 1685-95, 2013 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-23434367
ABSTRACT
6-Oxo and 6-thio analogs of purine were prepared based on the initial activity screening of a small, diverse purine library against Mycobacterium tuberculosis (Mtb). Certain 6-oxo and 6-thio-substituted purine analogs described herein showed moderate to good inhibitory activity. N(9)-substitution apparently enhances the anti-mycobacterial activity in the purine series described herein. Several 2-amino and 2-chloro purine analogs were also synthesized that showed moderate inhibitory activity against Mtb.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Purinas
/
Tuberculose
/
Mycobacterium tuberculosis
/
Antituberculosos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos