Expression of CD7, CD20 and CDX-2 in a secondary signet-ring cell tumor of the prostate: a case report.
Int J Immunopathol Pharmacol
; 26(1): 269-72, 2013.
Article
em En
| MEDLINE
| ID: mdl-23527733
ABSTRACT
As is well-known, signet ring cell carcinoma (SRCC) rarely appears as a histological finding in the prostatic tissue. Nevertheless, a differentiation should be made between a primary tumor and a metastatic disease. We describe the case of a 52-year-old man with lower urinary tract symptoms, serum total PSA of 0.2 ng/ml, elevated serum CEA and CA19-9 levels. Two years prior to presentation, he underwent total gastrectomy with histological findings indicating poor differentiated adenocarcinoma with signet-ring cell. A palpable nodule was found on digital rectal examination and for this reason he underwent 12-core transperineal prostate biopsy with a diagnosis of poor differentiated adenocarcinoma with signet-ring cell and adipose tissue infiltration. Immunohistochemical examinations revealed positivity for PAS, CK7 and CDX-2, focal positivity for CK20 and negativity for PSA and PSAP. The diagnosis of a prostatic secondary SRCC was possible given the positivity to CK7, CDX-2, focal positivity to CK20 and negativity to PSA.
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Bases de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Transativadores
/
Carcinoma de Células em Anel de Sinete
/
Proteínas de Homeodomínio
/
Antígenos CD7
/
Antígenos CD20
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Immunopathol Pharmacol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
PATOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article