ω-Transaminase from Ochrobactrum anthropi is devoid of substrate and product inhibitions.
Appl Environ Microbiol
; 79(13): 4141-4, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23584786
ABSTRACT
ω-Transaminases display complicated inhibitions by ketone products and both enantiomers of amine substrates. Here, we report the first example of ω-transaminase devoid of such inhibitions. Owing to the lack of enzyme inhibitions, the ω-transaminase from Ochrobactrum anthropi enabled efficient kinetic resolution of α-methylbenzylamine (500 mM) even without product removal.
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Fenetilaminas
/
Ochrobactrum anthropi
/
Inibidores Enzimáticos
/
Transaminases
Idioma:
En
Revista:
Appl Environ Microbiol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Coréia do Sul