Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma.
J Cutan Pathol
; 40(7): 646-50, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23590728
ABSTRACT
BACKGROUND:
Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs.METHODS:
We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD.RESULTS:
We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4.CONCLUSIONS:
We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma de Células Escamosas
/
Biomarcadores Tumorais
/
Regulação da Expressão Gênica
/
Queratina-7
/
Queratinas
/
Proteínas de Neoplasias
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos