Persufflation (gaseous oxygen perfusion) as a method of heart preservation.
J Cardiothorac Surg
; 8: 105, 2013 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-23607734
ABSTRACT
Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Preservação de Órgãos
/
Coração
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Cardiothorac Surg
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos