Individual differences in pain sensitivity vary as a function of precuneus reactivity.
Brain Topogr
; 27(3): 366-74, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-23636269
ABSTRACT
Although humans differ widely in how sensitive they are to painful stimuli, the neural correlates underlying such variability remains poorly understood. A better understanding of this is important given that baseline pain sensitivity scores relate closely to the risk of developing refractory, chronic pain. To address this, we used a matched perception paradigm which allowed us to control for individual variations in subjective experience. By measuring subjective pain, nociceptive flexion reflexes, and, somatosensory evoked brain potentials (with source localization analysis), we were able to map the brain's sequential response to pain while also investigating its relationship to pain sensitivity (i.e. change in the stimulation strength necessary to experience pain) and spinal cord activity. We found that pain sensitivity in healthy adults was closely tied to pain-evoked responses in the contralateral precuneus. Importantly, the precuneus did not contribute to the actual representation of pain in the brain, suggesting that pain sensitivity and pain representation depend on separate neuronal sub-systems.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Lobo Parietal
/
Percepção da Dor
/
Individualidade
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Revista:
Brain Topogr
Assunto da revista:
CEREBRO
Ano de publicação:
2014
Tipo de documento:
Article