Inflammatory hypertrophic cauda equina following intrathecal neural stem cell injection.
Muscle Nerve
; 48(5): 831-5, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23740462
ABSTRACT
INTRODUCTION:
Potential benefit from stem cell treatments has more patients seeking treatment without understanding possible risks.METHODS:
We describe a woman who presented with progressive bilateral leg pain, numbness, and gait difficulties. A prior stroke, macular degeneration, osteoarthritis, and depression, led her to receive intrathecal neural stem cell therapy overseas 1 year before onset of symptoms.RESULTS:
Imaging showed marked enlargement of lumbosacral roots of the cauda equina, which was not seen before stem cell treatment. Electrodiagnostic studies confirmed chronic multiple lumbosacral radiculopathies. Biopsy of a lumbar dorsal sensory root showed myelinated fiber degeneration and loss, with endoneurial inflammation. The hypertrophic inflammatory cauda equina syndrome was potentially triggered by the prior intrathecal neural stem cell injection.CONCLUSIONS:
Safety of intrathecal stem cell treatments is not routinely regulated in overseas stem cell facilities. We wish to bring this potential complication to the attention of health care providers.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Polirradiculopatia
/
Transplante de Células-Tronco
/
Células-Tronco Neurais
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Aged80
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Female
/
Humans
Idioma:
En
Revista:
Muscle Nerve
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos