Cryptocaryols A and B: total syntheses, stereochemical revision, structure elucidation, and structure-activity relationship.
J Am Chem Soc
; 135(25): 9334-7, 2013 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-23750754
ABSTRACT
The first total syntheses and structural elucidation of cryptocaryol A and cryptocaryol B were achieved in 23 and 25 linear steps, respectively. The synthesis relied on the use of a key pseudo-Cs symmetric pentaol intermediate, which in a stereochemically divergent manner was converted into either enantiomer as well as diastereomers. This synthetic effort enabled the first structure-activity relationships of this class of PDCD4 stabilizing natural products.
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Pironas
/
Proteínas de Ligação a RNA
/
Proteínas Reguladoras de Apoptose
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos