Withdrawal of GnRH agonist decreases oestradiol and VEGF concentrations in high responders.
Reprod Biomed Online
; 27(2): 131-9, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23764202
ABSTRACT
This study evaluated whether the withdrawal of a gonadotrophin-releasing hormone (GnRH) agonist before triggering ovulation reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk infertility patients who were treated with gonadotrophins. GnRH agonist was withdrawn for 2 or 3 days when dominant follicles were ≥14 mm in diameter, according to the GnRH agonist long protocol. Non-withdrawal of GnRH agonist was used as control. The serum concentration of oestradiol on the ovulation trigger day was significantly decreased in the GnRH agonist withdrawal group compared with the control group (5750.78 ± 2344.77 pg/ml versus 8076.43 ± 1981.67 pg/ml); however, the number of retrieved oocytes and the fertilization rate were similar between the groups. In addition, the concentrations of vascular endothelial growth factor in plasma on day of human chorionic gonadotrophin administration and follicular fluid on the oocyte retrieval day were decreased following GnRH agonist withdrawal. In fresh embryo transfer cycles, rates of clinical pregnancy, implantation and OHSS were not different between the groups. When GnRH agonist withdrawal was followed by total embryos cryopreserved, the rate of OHSS was decreased compared with the control group (0% versus 8.70%). Clinical pregnancy rates in cryopreserved embryo transfer cycles were comparable between the two groups.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Indução da Ovulação
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Hormônio Liberador de Gonadotropina
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Síndrome de Hiperestimulação Ovariana
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Fator A de Crescimento do Endotélio Vascular
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Estradiol
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Fármacos para a Fertilidade Feminina
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Infertilidade Feminina
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Guideline
/
Incidence_studies
/
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Reprod Biomed Online
Assunto da revista:
MEDICINA REPRODUTIVA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China