Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish.
Environ Sci Technol
; 47(15): 8793-800, 2013 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-23806087
ABSTRACT
While bisphenol S (BPS) has been frequently detected both in environment and biota, limited information is available on their effects of endocrine system. In the present study, adult zebrafish pairs were exposed to 0.5, 5, and 50 µg/L of BPS for 21 d, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BPS. Egg production and the gonadosomatic index in female fish were significantly decreased at ≥0.5 µg/L BPS. Plasma concentrations of 17ß-estradiol were significantly increased in both male and female fish. In male fish, however, significant decreases of testosterone concentration were observed along with up-regulation of cyp19a and down-regulation of cyp17 and 17ßhsd transcripts. Parental exposure to BPS resulted in delayed and lesser rates of hatching even when they were hatched in clean water. Continuous BPS exposure in the F1 embryos resulted in worse hatchability and increased malformation rates compared to those without BPS exposure. Our observations showed that exposure to low level BPS could affect the feedback regulatory circuits of HPG axis and impair the development of offspring.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fenóis
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Reprodução
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Sulfonas
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Peixe-Zebra
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Glândulas Endócrinas
Limite:
Animals
Idioma:
En
Revista:
Environ Sci Technol
Ano de publicação:
2013
Tipo de documento:
Article