Clinical use of a ceramide-based moisturizer for treating dogs with atopic dermatitis.
J Vet Sci
; 14(2): 199-205, 2013.
Article
em En
| MEDLINE
| ID: mdl-23814473
ABSTRACT
In humans, skin barrier dysfunction is thought to be responsible for enhanced penetration of allergens. Similar to conditions seen in humans, canine atopic dermatitis (CAD) is characterized by derangement of corneocytes and disorganization of intercellular lipids in the stratum corenum (SC) with decreased ceramide levels. This study was designed to evaluate the effects of a moisturizer containing ceramide on dogs with CAD. Dogs (n = 20, 3~8 years old) with mild to moderate clinical signs were recruited and applied a moisturizer containing ceramide for 4 weeks. Transepidermal water loss (TEWL), skin hydration, pruritus index for canine atopic dermatitis (PICAD) scores, and canine atopic dermatitis extent and severity index (CADESI) scores of all dogs were evaluated. Skin samples from five dogs were also examined with transmission electron microscopy (TEM) using ruthenium tetroxide. TEWL, PICAD, and CADESI values decreased (p < 0.05) and skin hydration increased dramatically over time (p < 0.05). Electron micrographs showed that the skin barrier of all five dogs was partially restored (p < 0.05). In conclusion, these results demonstrated that moisturizer containing ceramide was effective for treating skin barrier dysfunction and CAD symptoms.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ceramidas
/
Colesterol
/
Dermatite Atópica
/
Doenças do Cão
/
Emolientes
/
Ácidos Graxos não Esterificados
Tipo de estudo:
Etiology_studies
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Vet Sci
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2013
Tipo de documento:
Article