Biomarkers of tolerance.
Curr Opin Organ Transplant
; 18(4): 416-20, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23838646
ABSTRACT
PURPOSE OF REVIEW As the induction and maintenance of donor-specific tolerance is a central aim in solid organ transplantation, it is essential that clinicians are able to identify and monitor tolerance accurately and reliably. This review highlights recent advances in defining sets of biomarkers in noninvasive samples that may guide minimization and withdrawal of immunosuppression in tolerant recipients. RECENT FINDINGS:
Recent studies in liver and kidney transplant recipients have identified distinct biomarker profiles that are associated with operational tolerance. Although there is some heterogeneity in the findings of these studies, these have suggested novel cellular mechanisms for the development of tolerance.SUMMARY:
Multiple platforms such as microarray gene expression analysis, flow cytometry, and immune cell functional assays have been used to discover and validate composite sets of biomarkers, which identify recipients with operational tolerance both in liver and kidney transplantation. These studies suggest that distinct cellular and molecular mechanisms lead to the development of tolerance in different transplanted organs. These putative biomarker profiles now need to be validated prospectively in trials of immunosuppression withdrawal and in novel approaches to induce transplant tolerance.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Transplante de Fígado
/
Tolerância ao Transplante
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Organ Transplant
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Reino Unido