Effect of antiretroviral therapy on HIV reservoirs in elite controllers.
J Infect Dis
; 208(9): 1443-7, 2013 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-23847057
ABSTRACT
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent HIV and/or the dynamics of the infectious viral reservoirs in response to initiation and discontinuation of ART in elite controllers are unknown. We show that the size of the pool of CD4(+) T cells harboring infectious HIV diminished significantly after initiation of ART and rebounded to baseline upon cessation of therapy. Our data provide compelling evidence that persistent viral replication occurs in untreated elite controllers even in the absence of detectable plasma viremia.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Viremia
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Infecções por HIV
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HIV-1
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Fármacos Anti-HIV
Limite:
Humans
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2013
Tipo de documento:
Article