p66Shc, mitochondria, and the generation of reactive oxygen species.
Methods Enzymol
; 528: 99-110, 2013.
Article
em En
| MEDLINE
| ID: mdl-23849861
ABSTRACT
Reactive oxygen species (ROS), mainly originated from mitochondrial respiration, are critical inducers of oxidative damage and involved in tissue dysfunction. It is not clear, however, whether oxidative stress is the result of an active gene program or it is the by-product of physiological processes. Recent findings demonstrate that ROS are produced by mitochondria in a controlled way through specialized enzymes, including p66Shc, and take part in cellular process aimed to ensure adaptation and fitness. Therefore, genes generating specifically ROS are selected determinants of life span in response to different environmental conditions.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Mitocôndrias Hepáticas
/
Espécies Reativas de Oxigênio
/
Proteínas Adaptadoras da Sinalização Shc
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Enzymol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália