Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.
Clin Transl Oncol
; 16(1): 107-12, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-23896864
ABSTRACT
AIM:
The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer.METHODS:
Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls.RESULTS:
Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies.CONCLUSIONS:
Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
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Carcinoma Pulmonar de Células não Pequenas
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Predisposição Genética para Doença
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Neoplasias Pulmonares
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Transl Oncol
Ano de publicação:
2014
Tipo de documento:
Article