Endostatin levels and the risk of subsequent preeclampsia.
Eur J Obstet Gynecol Reprod Biol
; 170(2): 396-400, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23958573
ABSTRACT
OBJECTIVE:
To evaluate endostatin, an anti-angiogenic factor, in relation to the risk of preeclampsia (PE). STUDYDESIGN:
In this case control study, serum samples were collected at 11-17 weeks and 18-26 weeks' gestation. Endostatin levels were expressed as adjusted multiples of the median (MoM). Logistic regression was used to calculate adjusted odds ratios (aORs) for the prediction of PE.RESULTS:
A total of 77 women with PE and 150 controls were studied. Endostatin levels were significantly higher in women with PE compared to controls in both the first and the second trimester. At a cut-off level of 75th percentile of endostatin MoMs, the aORs for PE were 1.33 (95% confidence interval [CI], 0.68-2.58) at 11-17 weeks and 1.77 (95% CI, 0.94-3.34) at 18-26 weeks, after adjustment for ethnicity and chronic hypertension. The aORs for early-onset PE were 3.51 (95% CI, 1.18-10.43) at 11-17 weeks and 2.17 (95% CI, 0.67-7.06) at 18-26 weeks.CONCLUSIONS:
Higher endostatin levels are associated with an increased risk of early onset PE. Endostatin alone, however, has a poor predictive value for clinical usefulness.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Endostatinas
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Canadá