Interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis.
Iran J Immunol
; 10(3): 158-66, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-24076593
ABSTRACT
BACKGROUND:
Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes.OBJECTIVE:
To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptibility/resistance to brucellosis.METHODS:
The patient group included 196 patients suffering from Brucella infection and the control group consisted of 82 healthy animal husbandmen from the same geographical area. IL-8 (-251 A/C) and IL-6 (-174 C/G) gene polymorphisms were analyzed by PCR-RFLP and Allele Specific PCR (AS-PCR) respectively.RESULTS:
The frequency of -251 IL-8 AA genotype was significantly lower in the controls compared with that of the patients (p=0.0051), while the frequencies of other genotypes (AT and TT) and alleles (A and T) were not significantly different among the participants. No association was found between IL-6 (-174 C/G) polymorphism and brucellosis.CONCLUSION:
This study indicates that the IL-8 -251 AA genotype may be considered as a genetic susceptibility factor for brucellosis.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Brucella
/
Brucelose
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Interleucina-8
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Interleucina-6
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Predisposição Genética para Doença
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Iran J Immunol
Ano de publicação:
2013
Tipo de documento:
Article