Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development.
J Anat
; 224(1): 61-73, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24102585
ABSTRACT
The protein kinase C family (PKC) regulates a variety of neural functions including neurotransmitter release. The selective activation of a wide range of PKC isoforms in different cells and domains is likely to contribute to the functional diversity of PKC phosphorylating activity. In this review, we describe the isoform localization, phosphorylation function, regulation and signalling of the PKC family at the neuromuscular junction. Data show the involvement of the PKC family in several important functions at the neuromuscular junction and in particular in the maturation of the synapse and the modulation of neurotransmission in the adult.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
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Transmissão Sináptica
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Junção Neuromuscular
Limite:
Adult
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Humans
Idioma:
En
Revista:
J Anat
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Espanha