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Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development.
Lanuza, Maria A; Santafe, Manel M; Garcia, Neus; Besalduch, Núria; Tomàs, Marta; Obis, Teresa; Priego, Mercedes; Nelson, Phillip G; Tomàs, Josep.
Afiliação
  • Lanuza MA; Unitat d'Histologia i Neurobiologia (UHN), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
J Anat ; 224(1): 61-73, 2014 Jan.
Article em En | MEDLINE | ID: mdl-24102585
ABSTRACT
The protein kinase C family (PKC) regulates a variety of neural functions including neurotransmitter release. The selective activation of a wide range of PKC isoforms in different cells and domains is likely to contribute to the functional diversity of PKC phosphorylating activity. In this review, we describe the isoform localization, phosphorylation function, regulation and signalling of the PKC family at the neuromuscular junction. Data show the involvement of the PKC family in several important functions at the neuromuscular junction and in particular in the maturation of the synapse and the modulation of neurotransmission in the adult.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteína Quinase C / Transmissão Sináptica / Junção Neuromuscular Limite: Adult / Humans Idioma: En Revista: J Anat Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Proteína Quinase C / Transmissão Sináptica / Junção Neuromuscular Limite: Adult / Humans Idioma: En Revista: J Anat Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Espanha