Structural insights into transcription initiation by RNA polymerase II.
Trends Biochem Sci
; 38(12): 603-11, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24120742
ABSTRACT
Transcriptional regulation is one of the most important steps in control of cell identity, growth, differentiation, and development. Many signaling pathways controlling these processes ultimately target the core transcription machinery that, for protein coding genes, consists of RNA polymerase II (Pol II) and the general transcription factors (GTFs). New studies on the structure and mechanism of the core assembly and how it interfaces with promoter DNA and coactivator complexes have given tremendous insight into early steps in the initiation process, genome-wide binding, and mechanisms conserved for all nuclear and archaeal Pols. Here, we review recent developments in dissecting the architecture of the Pol II core machinery with a focus on early and regulated steps in transcription initiation.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
RNA Polimerase II
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos