Dynamic contrast-enhanced magnetic resonance imaging can assess vascularity within fracture non-unions and predicts good outcome.
Eur Radiol
; 24(2): 449-59, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24145951
ABSTRACT
OBJECTIVES:
To prospectively evaluate whether dynamic contrast-enhanced (DCE) MRI can assess vascularity within non-unions and predicts clinical outcome in combination with the clinical Non-Union Scoring System (NUSS).METHODS:
Fifty-eight patients with non-unions of extremities on CT underwent 3-T DCE MRI. Signal intensity curves obtained from a region-of-interest analysis were subdivided into those with more intense contrast agent uptake within the non-union than in adjacent muscle (vascularised non-union) and those with similar or less contrast uptake. The pharmacokinetic parameters of the Tofts model K trans, K ep, iAUC and V e were correlated with union at CT 1 year later (n = 49).RESULTS:
Despite inserted osteosynthetic material, DCE parameters could be evaluated in 57 fractures. The sensitivity/specificity of vascularised non-unions as an indicator of good outcome was 83.9%/50.0 % compared to 96.8%/33.3% using NUSS (n = 49). Logistic regression revealed a significant impact of NUSS on outcome (P = 0.04, odds ratio = 0.93). At first examination, median iAUC (initial area under the enhancement curve) for the ratio non-union/muscle was 10.28 in patients with good outcome compared with 3.77 in non-responders (P = 0.023). K trans, K ep and Ve within the non-union were not significantly different initially (n = 57) or 1 year later (n = 19).CONCLUSIONS:
DCE MRI can assess vascularity in fracture non-unions. A vascularised non-union correlates with good outcome. KEY POINTS ⢠Dynamic contrast-enhanced magnetic resonance imaging can assess vascularity within bony non-unions. ⢠Vascularised ununited fractures appear better at 1-year CT than poorly vascularised fractures. ⢠Non-union healing after osteosynthesis or osteoinductive drugs fundamentally requires vascularity. ⢠DCE MRI predicts treatment outcome better than the clinical Non-Union Scoring System. ⢠DCE MRI is clinically feasible to predict treatment outcome in bony non-unions.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Fraturas da Tíbia
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Fraturas da Ulna
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Imageamento por Ressonância Magnética
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Fraturas do Fêmur
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Fraturas não Consolidadas
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Fraturas do Úmero
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Meglumina
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Alemanha