Modulation of melanin synthesis by rengyolone isolated from the root of Eurya emarginata in melan-a cells.
Phytother Res
; 28(6): 940-5, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24255002
ABSTRACT
In the course of screening for the melanogenesis inhibitors, rengyolone was isolated from Eurya emarginata (Thumb) Makino. Its chemical structure was determined on the basis of spectroscopic analysis including mass spectroscopy and nuclear magnetic resonance analysis. Rengyolone inhibited potent melanogenesis in melan-a cells with an IC50 value of 65 µM without cytotoxicity. Also, rengyolone showed a melanin biosynthesis inhibition zone in a culture plate of Streptomyces bikiniensis, which is commonly used as an indicator organism. Moreover, rengyolone dramatically reduced protein expression of melanogenic enzyme, tyrosinase. Furthermore, rengyolone presented inhibition on the body pigmentation in zebrafish model system and decreased melanin contents and tyrosinase activity. These results suggest that rengyolone isolated from E. emarginata may be an effective skin-whitening agent that regulates the expression of melanogenic enzymes.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Magnoliopsida
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Furanos
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Compostos Heterocíclicos com 2 Anéis
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Melaninas
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Melanócitos
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2014
Tipo de documento:
Article