Shape-memory starch for resorbable biomedical devices.
Carbohydr Polym
; 99: 242-8, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24274502
ABSTRACT
Shape-memory resorbable materials were obtained by extrusion-cooking of potato starch with 20% glycerol under usual conditions. They presented an efficient shape-memory with a high recovery ratio (Rr>90%). Their recovery could be triggered at 37°C in water. After water immersion at 37°C, the modulus decreased from 1GPa to 2.4MPa and remained almost constant over 21 days. Gamma-ray sterilization did not have a dramatic impact on their mechanical properties, despite a large decrease of molecular mass analyzed by asymmetrical flow field-flow fractionation coupled with multi-angle laser light scattering (AFFFF-MALLS). Samples implanted in a rat model exhibited normal tissue integration with a low inflammatory response. Thus, as previously investigated in the case of shape-memory synthetic polymers, natural starch, without chemical grafting, can now be considered for manufacturing innovative biodegradable devices for less-invasive surgery.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Amido
/
Materiais Biocompatíveis
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Implantes Absorvíveis
Limite:
Animals
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2014
Tipo de documento:
Article