Prenatal diagnosis of Down syndrome in dizygotic twin pregnancy.
Ginekol Pol
; 84(11): 974-8, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24455857
ABSTRACT
We present a case of a 33-year-old pregnant woman who had a transvaginal ultrasound performed at week 9 of gestation. A dichorionic diamniotic twin pregnancy with symmetrically developing fetuses, was confirmed. Chromosomal defect markers (NT NB, DV TV) were analyzed in the first genetic test, performed according to the Fetal Medicine Foundation (FMF) criteria, and the double marker test was performed (PAPP-A protein and free beta-hCG concentrations in patient serum were determined). In the subsequent diagnostic procedures, the patient was offered and consented to amniopuncture after week 15 of gestation. The material obtained in the course of that invasive procedure allowed to identify a normal male karyotype - 46, XY in the first fetus (Fetus I). Cytogenetic analysis of the material from the second fetus (Fetus II) resulted in the diagnosis of an abnormal female karyotype - 47, XX, +21. Based on the analyzed clinical case, we present the difficulties of performing prenatal diagnosis in a dizygotic twin pregnancy The results prove the applicability and efficacy of prenatal diagnostics tests based on the FMF criteria also in twin pregnancies.
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Bases de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Gêmeos Dizigóticos
/
Síndrome de Down
/
Medição da Translucência Nucal
/
Doenças em Gêmeos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Ginekol Pol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Polônia